(3-14C) coumarin distribution in rat tissues after the injection of a single dose
Identifieur interne : 010221 ( Main/Exploration ); précédent : 010220; suivant : 010222(3-14C) coumarin distribution in rat tissues after the injection of a single dose
Auteurs : N. B. Piller [Australie]Source :
- Research in Experimental Medicine [ 0300-9130 ] ; 1977-02-01.
Descripteurs français
- KwdFr :
- MESH :
- métabolisme : Coumarines.
- Animaux, Femelle, Rats, Répartition dans les tissus.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Coumarins.
- Animals, Female, Rats, Tissue Distribution.
Abstract
Summary: Experimentally it has been shown that coumarin is a very effective therapy in the treatment of high protein oedemas. This study reports on the distribution of a single dose of 3-14C-coumarin in rats. Blood levels of coumarin were always much lower than those of the tissues at similar times. The half life of 3-14C-coumarin and its labelled metabolites was found to be about 43 hours. This ties in fairly well with the optimum frequencies of the administration of the drug which was found to be 24 hours. At this time, skin and muscle levels (the tissues most effected in lymphoedema and in thermal oedema) were maximal.
Url:
DOI: 10.1007/BF01851592
Affiliations:
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Le document en format XML
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B." last="Piller">N. B. Piller</name><affiliation wicri:level="2"><country>Australie</country><placeName><region type="state">Australie-Méridionale</region></placeName><wicri:cityArea>Electron Microscope Unit, Department of Zoology, University of Adelaide, P.O. Box 498, 5001, Adelaide</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Research in Experimental Medicine</title><title level="j" type="abbrev">Res. Exp. 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This study reports on the distribution of a single dose of 3-14C-coumarin in rats. Blood levels of coumarin were always much lower than those of the tissues at similar times. The half life of 3-14C-coumarin and its labelled metabolites was found to be about 43 hours. This ties in fairly well with the optimum frequencies of the administration of the drug which was found to be 24 hours. At this time, skin and muscle levels (the tissues most effected in lymphoedema and in thermal oedema) were maximal.</div></front></TEI><affiliations><list><country><li>Australie</li></country><region><li>Australie-Méridionale</li></region></list><tree><country name="Australie"><region name="Australie-Méridionale"><name sortKey="Piller, N B" sort="Piller, N B" uniqKey="Piller N" first="N. B." last="Piller">N. B. Piller</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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